Model evaluation for glycolytic oscillations in yeast biotransformations of xenobiotics
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چکیده
منابع مشابه
Model evaluation for glycolytic oscillations in yeast biotransformations of xenobiotics.
Anaerobic glycolysis in yeast perturbed by the reduction of xenobiotic ketones is studied numerically in two models which possess the same topology but different levels of complexity. By comparing both models' predictions for concentrations and fluxes as well as steady or oscillatory temporal behavior we answer the question what phenomena require what kind of minimum model abstraction. While me...
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We investigated a cell-population modelling technique in which the population is constructed from an ensemble of individual cell models. The average value or the number distribution of any intracellular property captured by the individual cell model can be calculated by simulation of a sufficient number of individual cells. The proposed method is applied to a simple model of yeast glycolytic os...
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Glycolytic oscillations of intact yeast cells of the strain Saccharomyces carlsbergensis were investigated at both the levels of cell populations and of individual cells. Individual cells showed glycolytic oscillations even at very low cell densities (e.g. 1.0 x 10(5) cells/ml). By contrast, the collective behaviour on the population level was cell density-dependent: at high cell densities it i...
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ژورنال
عنوان ژورنال: Biophysical Chemistry
سال: 2004
ISSN: 0301-4622
DOI: 10.1016/j.bpc.2003.12.004